Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids

Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids

Abstract Background Recurrence of retinoblastoma (RB) following chemoreduction is common and is often managed with local (intra-arterial/intravitreal) chemotherapy. However, some tumors are resistant to even local administration of maximum feasible drug dosages, or effective tumor control and globe...

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Bibliographic Details
Main Authors: Atthapol Srimongkol, Natanan Laosillapacharoen, Duangporn Saengwimol, Vijender Chaitankar, Duangnate Rojanaporn, Thanastha Thanomchard, Suparerk Borwornpinyo, Suradej Hongeng, Rossukon Kaewkhaw
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Sunitinib
Retinoblastoma
Drug screening
Organoid
Retinal toxicity
Online Access:https://doi.org/10.1186/s13046-023-02608-1

Internet

https://doi.org/10.1186/s13046-023-02608-1

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