Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.

Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.

BACKGROUND:The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesis by the induction of VSG RNAi triggers an unusual...

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Bibliographic Details
Main Authors: Terry K Smith, Nadina Vasileva, Eva Gluenz, Stephen Terry, Neil Portman, Susanne Kramer, Mark Carrington, Shulamit Michaeli, Keith Gull, Gloria Rudenko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2762041?pdf=render

Internet

http://europepmc.org/articles/PMC2762041?pdf=render

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