Biochemical Characterization of SARS-CoV-2 Spike RBD Mutations and Their Impact on ACE2 Receptor Binding

Biochemical Characterization of SARS-CoV-2 Spike RBD Mutations and Their Impact on ACE2 Receptor Binding

Infection of mammalian cells by SARS-CoV-2 coronavirus requires primary interaction between the receptor binding domain (RBD) of the viral spike protein and the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) glycoprotein. Several mutations in the RBD of SARS-CoV-2 spike protein ha...

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Bibliographic Details
Main Authors: Abdullah Hoter, Hassan Y. Naim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
SARS-CoV-2
spike
ACE2 interaction
RBD
double mutant
transmissibility
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.893843/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.893843/full

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