Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice

Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice

Abstract Huntington’s Disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment due to the expansion of a polyglutamine (CAG) repeat in the N-terminal region of the huntingtin (Htt) protein. The creation of HD mouse models rep...

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Bibliographic Details
Main Authors: Si Han Li, Tash-Lynn L. Colson, Jingwei Chen, Khaled S. Abd-Elrahman, Stephen S. G. Ferguson
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Molecular Brain
Subjects:
Neurodegenerative diseases
Huntingtin
Sex differences
Mouse model
Motor function
Online Access:https://doi.org/10.1186/s13041-023-01054-6

Internet

https://doi.org/10.1186/s13041-023-01054-6

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