A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer

A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer

Overcoming resistance is one of the most challenging features in current anticancer therapy. Autophagy is a cellular process that confers resistance in some advanced tumors, since it enables cancer cells to adapt to stressful situations, such as anticancer treatments. Hence, the inhibition of this c...

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Bibliographic Details
Main Authors: Adrià Molero-Valenzuela, Pere Fontova, Daniel Alonso-Carrillo, Israel Carreira-Barral, Ana Aurora Torres, María García-Valverde, Cristina Benítez-García, Ricardo Pérez-Tomás, Roberto Quesada, Vanessa Soto-Cerrato
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
autophagy
treatment resistance
autophagy inhibitor
lysosomal dysfunction
anionophore
lung cancer
Online Access:https://www.mdpi.com/2072-6694/14/14/3387

Internet

https://www.mdpi.com/2072-6694/14/14/3387

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