Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib

Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib

Backgrounds: Brain metastases occur in approximately 30% of patients with non-small-cell lung cancer (NSCLC). Therefore, the free drug concentration in cerebrospinal fluid (CSF) is strongly associated with the clinical efficacy.Purpose: The present study aimed to develop physiologically based pharma...

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Bibliographic Details
Main Authors: Bole Li, Shan Liu, Honglei Feng, Chunshuang Du, Liman Wei, Jie Zhang, Guangwei Jia, Chunnuan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
ALK inhibitors
PBPK model
ALK occupancy
optimal dosing regimen
concentration prediction in cerebrospinal fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1234262/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1234262/full

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