mRNA-Based Vaccines Are Highly Immunogenic and Confer Protection in the Gnotobiotic Pig Model of Human Rotavirus Diarrhea

mRNA-Based Vaccines Are Highly Immunogenic and Confer Protection in the Gnotobiotic Pig Model of Human Rotavirus Diarrhea

Human rotavirus (HRV) is still a leading cause of severe dehydrating gastroenteritis globally, particularly in infants and children. Previously, we demonstrated the immunogenicity of mRNA-based HRV vaccine candidates expressing the viral spike protein VP8* in rodent models. In the present study, we...

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Bibliographic Details
Main Authors: Casey Hensley, Sandro Roier, Peng Zhou, Sofia Schnur, Charlotte Nyblade, Viviana Parreno, Annie Frazier, Maggie Frazier, Kelsey Kiley, Samantha O’Brien, Yu Liang, Bryan T. Mayer, Ruizhe Wu, Celia Mahoney, Monica M. McNeal, Benjamin Petsch, Susanne Rauch, Lijuan Yuan
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Vaccines
Subjects:
rotavirus
mRNA vaccine
gnotobiotic pigs
P2-VP8*
diarrhea
Online Access:https://www.mdpi.com/2076-393X/12/3/260

Internet

https://www.mdpi.com/2076-393X/12/3/260

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