CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma

CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma

CD133, a cancer stem cell (CSC) marker in tumors, including melanoma, is associated with tumor recurrence, chemoresistance, and metastasis. Patient-derived melanoma cell lines were transduced with a Tet-on vector expressing CD133, generating doxycycline (Dox)-inducible cell lines. Cells were exposed...

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Bibliographic Details
Main Authors: Cynthia M Simbulan-Rosenthal, Nusrat Islam, Yogameenakshi Haribabu, Ryyan Alobaidi, Azadeh Shalamzari, Garrett Graham, Li-Wei Kuo, Peter Sykora, Dean S Rosenthal
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Cells
Subjects:
melanoma initiating cells
melanoma stem cells
CD133
AREG
EGFR
MAPK pathway
Online Access:https://www.mdpi.com/2073-4409/13/9/777

Internet

https://www.mdpi.com/2073-4409/13/9/777

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