Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics

Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics

The aim of the present study was to establish an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of orelabrutinib in rat plasma using futibatinib as internal standard (IS), and to apply it for a pharmacokinetic study in rats. Orelabrutinib w...

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Bibliographic Details
Main Authors: Ya-nan Liu, Yingying Hu, Jing Wang, Chaojie Chen, Jianping Cai, Ren-ai Xu, Zhongqiu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
pharmacokinetic
UPLC-MS/MS
orelabrutinib
protein precipitation
methodological verification
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.991281/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.991281/full

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