Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia
Background and objectiveThe cortico–hippocampal network is an emerging neural framework with striking evidence that it supports cognition in humans, especially memory; this network includes the anterior temporal (AT) system, the posterior medial (PM) system, the anterior hippocampus (aHIPPO), and th...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1167942/full |
| _version_ | 1827932932515299328 |
|---|---|
| author | Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Xueqin Song Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng |
| author_facet | Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Xueqin Song Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng |
| author_sort | Kangkang Xue |
| collection | DOAJ |
| description | Background and objectiveThe cortico–hippocampal network is an emerging neural framework with striking evidence that it supports cognition in humans, especially memory; this network includes the anterior temporal (AT) system, the posterior medial (PM) system, the anterior hippocampus (aHIPPO), and the posterior hippocampus (pHIPPO). This study aimed to detect aberrant patterns of functional connectivity within and between large-scale cortico–hippocampal networks in first-episode schizophrenia patients compared with a healthy control group via resting-state functional magnetic resonance imaging (rs-fMRI) and to explore the correlations of these aberrant patterns with cognition.MethodsA total of 86 first-episode, drug-naïve schizophrenia patients and 102 healthy controls (HC) were recruited to undergo rs-fMRI examinations and clinical evaluations. We conducted large-scale edge-based network analysis to characterize the functional architecture of the cortico–hippocampus network and investigate between-group differences in within/between-network functional connectivity. Additionally, we explored the associations of functional connectivity (FC) abnormalities with clinical characteristics, including scores on the Positive and Negative Syndrome Scale (PANSS) and cognitive scores.ResultsCompared with the HC group, schizophrenia patients exhibited widespread alterations to within-network FC of the cortico–hippocampal network, with decreases in FC involving the precuneus (PREC), amygdala (AMYG), parahippocampal cortex (PHC), orbitofrontal cortex (OFC), perirhinal cortex (PRC), retrosplenial cortex (RSC), posterior cingulate cortex (PCC), angular gyrus (ANG), aHIPPO, and pHIPPO. Schizophrenia patients also showed abnormalities in large-scale between-network FC of the cortico–hippocampal network, in the form of significantly decreased FC between the AT and the PM, the AT and the aHIPPO, the PM and the aHIPPO, and the aHIPPO and the pHIPPO. A number of these signatures of aberrant FC were correlated with PANSS score (positive, negative, and total score) and with scores on cognitive test battery items, including attention/vigilance (AV), working memory (WM), verbal learning and memory (Verb_Lrng), visual learning and memory (Vis_Lrng), reasoning and problem-solving (RPS), and social cognition (SC).ConclusionSchizophrenia patients show distinct patterns of functional integration and separation both within and between large-scale cortico–hippocampal networks, reflecting a network imbalance of the hippocampal long axis with the AT and PM systems, which regulate cognitive domains (mainly Vis_Lrng, Verb_Lrng, WM, and RPS), and particularly involving alterations to FC of the AT system and the aHIPPO. These findings provide new insights into the neurofunctional markers of schizophrenia. |
| first_indexed | 2024-03-13T07:17:28Z |
| format | Article |
| id | doaj.art-cb5c2e5906e54613a19169eee61f9a44 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T07:17:28Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-cb5c2e5906e54613a19169eee61f9a442023-06-05T05:01:54ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11679421167942Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophreniaKangkang Xue0Kangkang Xue1Kangkang Xue2Kangkang Xue3Kangkang Xue4Kangkang Xue5Kangkang Xue6Kangkang Xue7Jingli Chen8Jingli Chen9Jingli Chen10Jingli Chen11Jingli Chen12Jingli Chen13Jingli Chen14Jingli Chen15Yarui Wei16Yarui Wei17Yarui Wei18Yarui Wei19Yarui Wei20Yarui Wei21Yarui Wei22Yarui Wei23Yuan Chen24Yuan Chen25Yuan Chen26Yuan Chen27Yuan Chen28Yuan Chen29Yuan Chen30Yuan Chen31Shaoqiang Han32Shaoqiang Han33Shaoqiang Han34Shaoqiang Han35Shaoqiang Han36Shaoqiang Han37Shaoqiang Han38Shaoqiang Han39Caihong Wang40Caihong Wang41Caihong Wang42Caihong Wang43Caihong Wang44Caihong Wang45Caihong Wang46Caihong Wang47Yong Zhang48Yong Zhang49Yong Zhang50Yong Zhang51Yong Zhang52Yong Zhang53Yong Zhang54Yong Zhang55Xueqin Song56Jingliang Cheng57Jingliang Cheng58Jingliang Cheng59Jingliang Cheng60Jingliang Cheng61Jingliang Cheng62Jingliang Cheng63Jingliang Cheng64Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, ChinaEngineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, ChinaEngineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, ChinaKey Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, ChinaKey Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, ChinaKey Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, ChinaEngineering Research Center of Brain Function Development and Application of Henan Province, Zhengzhou, ChinaBackground and objectiveThe cortico–hippocampal network is an emerging neural framework with striking evidence that it supports cognition in humans, especially memory; this network includes the anterior temporal (AT) system, the posterior medial (PM) system, the anterior hippocampus (aHIPPO), and the posterior hippocampus (pHIPPO). This study aimed to detect aberrant patterns of functional connectivity within and between large-scale cortico–hippocampal networks in first-episode schizophrenia patients compared with a healthy control group via resting-state functional magnetic resonance imaging (rs-fMRI) and to explore the correlations of these aberrant patterns with cognition.MethodsA total of 86 first-episode, drug-naïve schizophrenia patients and 102 healthy controls (HC) were recruited to undergo rs-fMRI examinations and clinical evaluations. We conducted large-scale edge-based network analysis to characterize the functional architecture of the cortico–hippocampus network and investigate between-group differences in within/between-network functional connectivity. Additionally, we explored the associations of functional connectivity (FC) abnormalities with clinical characteristics, including scores on the Positive and Negative Syndrome Scale (PANSS) and cognitive scores.ResultsCompared with the HC group, schizophrenia patients exhibited widespread alterations to within-network FC of the cortico–hippocampal network, with decreases in FC involving the precuneus (PREC), amygdala (AMYG), parahippocampal cortex (PHC), orbitofrontal cortex (OFC), perirhinal cortex (PRC), retrosplenial cortex (RSC), posterior cingulate cortex (PCC), angular gyrus (ANG), aHIPPO, and pHIPPO. Schizophrenia patients also showed abnormalities in large-scale between-network FC of the cortico–hippocampal network, in the form of significantly decreased FC between the AT and the PM, the AT and the aHIPPO, the PM and the aHIPPO, and the aHIPPO and the pHIPPO. A number of these signatures of aberrant FC were correlated with PANSS score (positive, negative, and total score) and with scores on cognitive test battery items, including attention/vigilance (AV), working memory (WM), verbal learning and memory (Verb_Lrng), visual learning and memory (Vis_Lrng), reasoning and problem-solving (RPS), and social cognition (SC).ConclusionSchizophrenia patients show distinct patterns of functional integration and separation both within and between large-scale cortico–hippocampal networks, reflecting a network imbalance of the hippocampal long axis with the AT and PM systems, which regulate cognitive domains (mainly Vis_Lrng, Verb_Lrng, WM, and RPS), and particularly involving alterations to FC of the AT system and the aHIPPO. These findings provide new insights into the neurofunctional markers of schizophrenia.https://www.frontiersin.org/articles/10.3389/fnins.2023.1167942/fullschizophreniafunctional connectivitymagnetic resonance imagingcognitionhippocampus |
| spellingShingle | Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Kangkang Xue Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Jingli Chen Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yarui Wei Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Yuan Chen Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Shaoqiang Han Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Caihong Wang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Yong Zhang Xueqin Song Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Jingliang Cheng Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia Frontiers in Neuroscience schizophrenia functional connectivity magnetic resonance imaging cognition hippocampus |
| title | Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia |
| title_full | Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia |
| title_fullStr | Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia |
| title_full_unstemmed | Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia |
| title_short | Impaired large-scale cortico–hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia |
| title_sort | impaired large scale cortico hippocampal network connectivity including the anterior temporal and posterior medial systems and its associations with cognition in patients with first episode schizophrenia |
| topic | schizophrenia functional connectivity magnetic resonance imaging cognition hippocampus |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1167942/full |
| work_keys_str_mv | AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT kangkangxue impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jinglichen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yaruiwei impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yuanchen impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT shaoqianghan impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT caihongwang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT yongzhang impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT xueqinsong impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia AT jingliangcheng impairedlargescalecorticohippocampalnetworkconnectivityincludingtheanteriortemporalandposteriormedialsystemsanditsassociationswithcognitioninpatientswithfirstepisodeschizophrenia |