Computational analysis of genes with lethal knockout phenotype and prediction of essential genes in archaea

Computational analysis of genes with lethal knockout phenotype and prediction of essential genes in archaea

ABSTRACTThe identification of microbial genes essential for survival as those with lethal knockout phenotype (LKP) is a common strategy for functional interrogation of genomes. However, interpretation of the LKP is complicated because a substantial fraction of the genes with this phenotype remains p...

Full description

Bibliographic Details
Main Authors: Kira S. Makarova, Changyi Zhang, Yuri I. Wolf, Svetlana Karamycheva, Rachel J. Whitaker, Eugene V. Koonin
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
essential genes
GINS
KEOPS complex
toxin/antitoxin systems
aspartic protease
archaea
Online Access:https://journals.asm.org/doi/10.1128/mbio.03092-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03092-23

Similar Items