Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice

Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice

Background: Surgery and anesthesia-induced perioperative neurocognitive disorder (PND) are closely related to NOD-like receptors (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome microglia inflammatory response. Inhibiting the occurrence of neuroinflammation is an important treatment meth...

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Bibliographic Details
Main Authors: Lieliang Zhang, Fan Xiao, Jing Zhang, Xifeng Wang, Jun Ying, Gen Wei, Shoulin Chen, Xiangfei Huang, Wen Yu, Xing Liu, Qingcui Zheng, Guohai Xu, Shuchun Yu, Fuzhou Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
dexmedetomidine
microglial
neuroinflammation
NLRP3 inflammasome
perioperative neurocognitive disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.646265/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.646265/full

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