Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants

Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants

Acute cellular rejection remains a significant obstacle affecting successful outcomes of organ transplantation including vascularized composite tissue allografts (VCA). Donor antigen presenting cells (APCs), particularly dendritic cells (DCs), orchestrate early alloimmune responses by activating rec...

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Bibliographic Details
Main Authors: Muhammad Imtiaz Ashraf, Joerg Mengwasser, Anja Reutzel-Selke, Dietrich Polenz, Kirsten Führer, Steffen Lippert, Peter Tang, Edward Michaelis, Rusan Catar, Johann Pratschke, Christian Witzel, Igor M. Sauer, Stefan G. Tullius, Barbara Kern
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
acute cellular rejection
vascularized composite-tissue allografts (VCA)
antigen presenting cells (APCs)
conventional dendritic cells (cDCs)
allograft immunogenicity
mouse models of skin and hind limb transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1395945/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1395945/full

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