Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer

Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer

Abstract Background Patients with triple-negative breast cancer (TNBC) often have poorer prognosis than those with other subtypes because of its aggressive behaviors. Cancer cells are heterogeneous, and only a few highly metastatic subclones metastasize. Although the majority of subclones may not me...

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Bibliographic Details
Main Authors: Chunning Li, Teizo Yoshimura, Miao Tian, Yuze Wang, Takamasa Kondo, Ken-Ichi Yamamoto, Masayoshi Fujisawa, Toshiaki Ohara, Masakiyo Sakaguchi, Akihiro Matsukawa
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Metastasis
Exosomes
Epithelial mesenchymal transition
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13058-022-01557-5

Internet

https://doi.org/10.1186/s13058-022-01557-5

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