Integrated transcriptomics contrasts fatty acid metabolism with hypoxia response in β-cell subpopulations associated with glycemic control

Integrated transcriptomics contrasts fatty acid metabolism with hypoxia response in β-cell subpopulations associated with glycemic control

Abstract Background Understanding how heterogeneous β-cell function impacts diabetes is imperative for therapy development. Standard single-cell RNA sequencing analysis illuminates some factors driving heterogeneity, but new strategies are required to enhance information capture. Results We integrat...

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Bibliographic Details
Main Authors: Mario A Miranda, Juan F Macias-Velasco, Heather Schmidt, Heather A Lawson
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Genomics
Subjects:
Single-cell RNAseq
Bulk RNAseq
Hyperglycemia
Insulin
β-cell heterogeneity
Diabetes
Online Access:https://doi.org/10.1186/s12864-023-09232-5

Internet

https://doi.org/10.1186/s12864-023-09232-5

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