Excess CD40L does not rescue anti-DNA B cells from clonal anergy [v2; ref status: indexed, http://f1000r.es/2rs]
CD40L, a member of the tumor necrosis factor (TNF) ligand family, is overexpressed in patients with systemic lupus erythematosus and in lupus mouse models. Previously, we demonstrated that B cells producing pathogenic anti-Sm/RNP antibodies are deleted in the splenic marginal zone (MZ), and that MZ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2014-01-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/2-218/v2 |