Schisandrin A Attenuates Diabetic Nephropathy via EGFR/AKT/GSK3β Signaling Pathway Based on Network Pharmacology and Experimental Validation

Schisandrin A Attenuates Diabetic Nephropathy via EGFR/AKT/GSK3β Signaling Pathway Based on Network Pharmacology and Experimental Validation

Diabetic nephropathy (DN) is one of the common complications of diabetes and the main cause of end-stage renal disease (ESRD) in clinical practice. Schisandrin A (Sch A) has multiple pharmacological activities, including inhibiting fibrosis, reducing apoptosis and oxidative stress, and regulating im...

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Bibliographic Details
Main Authors: Pengyu Wang, Qing Lan, Qi Huang, Ruyi Zhang, Shuo Zhang, Leiming Yang, Yan Song, Tong Wang, Guandi Ma, Xiufen Liu, Xiying Guo, Youzhi Zhang, Chao Liu
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Biology
Subjects:
Schisandrin A
diabetic nephropathy
EGFR
AKT/GSK-3β
network pharmacology
rat
Online Access:https://www.mdpi.com/2079-7737/13/8/597

Internet

https://www.mdpi.com/2079-7737/13/8/597

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