Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties.

Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties.

Head and neck squamous carcinoma (HNSCC) tumors carry dismal long-term prognosis and the role of tumor initiating cells (TICs) in this cancer is unclear. We investigated in HNSCC xenografts whether specific tumor subpopulations contributed to tumor growth. We used a CFSE-based label retentions assay...

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Bibliographic Details
Main Authors: Paloma Bragado, Yeriel Estrada, Maria Soledad Sosa, Alvaro Avivar-Valderas, David Cannan, Eric Genden, Marita Teng, Aparna C Ranganathan, Huei-Chi Wen, Avnish Kapoor, Emily Bernstein, Julio A Aguirre-Ghiso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3262798?pdf=render

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http://europepmc.org/articles/PMC3262798?pdf=render

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