Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue

Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue

Summary: Human breast cancer cells are known to activate adjacent “normal-like” cells to enhance their own growth, but the cellular and molecular mechanisms involved are poorly understood. We now show by both phenotypic and functional measurements that normal human mammary progenitor cells are signi...

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Bibliographic Details
Main Authors: Sumanta Chatterjee, Pratima Basak, Edward Buchel, Janice Safneck, Leigh C. Murphy, Michael Mowat, Sam K. Kung, Peter Eirew, Connie J. Eaves, Afshin Raouf
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Stem Cell Reports
Subjects:
breast cancer
activated stromal fibroblasts
TGF-β
tumor-adjacent tissue
suppression of normal breast tissue progenitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117304885

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http://www.sciencedirect.com/science/article/pii/S2213671117304885

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