Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance

Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance

Multidrug resistance (MDR) of tumor cells to chemotherapeutic agents is the main reason for the failure of cancer chemotherapy. Overexpression of ABCB1 transporter that actively pumps various drugs out of the cells has been considered a major contributing factor for MDR. Over the past decade, many a...

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Bibliographic Details
Main Authors: Xiaofang Luo, Qiu-Xu Teng, Jin-Yun Dong, Dong-Hua Yang, Meifeng Wang, Wubliker Dessie, Jiang-Jiang Qin, Zi-Ning Lei, Jing-Quan Wang, Zuodong Qin, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
multidrug resistance
ABC transporter
antimicrobial peptide HX-12C
reversal agents
combination therapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01208/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01208/full

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