Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan

Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan

Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility. In this study, we enhanced the solubility, bioavailability, and stability of TEL through the fabrication of TEL-loaded pH-modulated solid dispe...

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Detaylı Bibliyografya
Asıl Yazarlar: Bhupendra Raj Giri, Jaewook Kwon, Anh Q. Vo, Ajinkya M. Bhagurkar, Suresh Bandari, Dong Wuk Kim
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: MDPI AG 2021-01-01
Seri Bilgileri:Pharmaceuticals
Konular:
telmisartan
pH-modifier
solid dispersion
hot-melt extrusion (HME)
solubility
bioavailability
Online Erişim:https://www.mdpi.com/1424-8247/14/1/73

Internet

https://www.mdpi.com/1424-8247/14/1/73

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