Development of a new vesicular formulation for delivery of Ifosfamide: Evidence from in vitro, in vivo, and in silico experiments

Development of a new vesicular formulation for delivery of Ifosfamide: Evidence from in vitro, in vivo, and in silico experiments

Ifosfamide (IFO) is a member of the oxazaphosphorine family of alkylating drugs that exhibits anticancer and immunoregulatory properties. The toxicity of IFO is dose-limited because of its biotransformation into highly reactive metabolites, including acrolein and chloroacetaldehyde. Here, we aimed t...

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Bibliographic Details
Main Authors: Mohammad Reza Hajinezhad, Sheida Shahraki, Zahra Nikfarjam, Fatemeh Davodabadi, Shekoufeh Mirinejad, Abbas Rahdar, Saman Sargazi, Mahmood Barani
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Arabian Journal of Chemistry
Subjects:
Drug delivery system
Ifosfamide
Molecular dynamics simulation
Niosome
Toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223005488

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http://www.sciencedirect.com/science/article/pii/S1878535223005488

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