Evaluation of Cx43 Gap Junction Inhibitors Using a Quantitative Structure-Activity Relationship Model

Evaluation of Cx43 Gap Junction Inhibitors Using a Quantitative Structure-Activity Relationship Model

Gap junctions (GJs) made of connexin-43 (Cx43) are necessary for the conduction of electrical impulses in the heart. Modulation of Cx43 GJ activity may be beneficial in the treatment of cardiac arrhythmias and other dysfunctions. The search for novel GJ-modulating agents using molecular docking allo...

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Bibliographic Details
Main Authors: Ramona Matusevičiūtė, Eglė Ignatavičiūtė, Rokas Mickus, Sergio Bordel, Vytenis Arvydas Skeberdis, Vytautas Raškevičius
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomedicines
Subjects:
Cx43
gap junctions
conductance
inhibitors
docking
IC<sub>50</sub>
Online Access:https://www.mdpi.com/2227-9059/11/7/1972

Internet

https://www.mdpi.com/2227-9059/11/7/1972

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