Characterization and Engineering Studies of a New Endolysin from the <i>Propionibacterium acnes</i> Bacteriophage PAC1 for the Development of a Broad-Spectrum Artilysin with Altered Specificity

The emergence of multidrug-resistant (MDR) bacteria has risen rapidly, leading to a great threat to global public health. A promising solution to this problem is the exploitation of phage endolysins. In the present study, a putative N-acetylmuramoyl-L-alanine type-2 amidase (NALAA-2, EC 3.5.1.28) fr...

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Bibliographic Details
Main Authors: Christina Varotsou, Georgios E. Premetis, Nikolaos E. Labrou
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/24/10/8523