Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung carcinoma (NSCLC) to identify novel, clinically target...

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Bibliographic Details
Main Authors: Marina Laplana, Matthias Bieg, Christian Faltus, Svitlana Melnik, Olga Bogatyrova, Zuguang Gu, Thomas Muley, Michael Meister, Hendrik Dienemann, Esther Herpel, Christopher I. Amos, Matthias Schlesner, Roland Eils, Christoph Plass, Angela Risch
Format: Article
Language:English
Published: Taylor & Francis Group 2022-02-01
Series:Epigenetics
Subjects:
risk snps
bisulphite sequencing
dna methylation
enhancers
lung cancer
dmr
Online Access:http://dx.doi.org/10.1080/15592294.2021.1878723

Internet

http://dx.doi.org/10.1080/15592294.2021.1878723

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