Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung carcinoma (NSCLC) to identify novel, clinically target...

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Detalhes bibliográficos
Main Authors: Marina Laplana, Matthias Bieg, Christian Faltus, Svitlana Melnik, Olga Bogatyrova, Zuguang Gu, Thomas Muley, Michael Meister, Hendrik Dienemann, Esther Herpel, Christopher I. Amos, Matthias Schlesner, Roland Eils, Christoph Plass, Angela Risch
Formato: Artigo
Idioma:English
Publicado em: Taylor & Francis Group 2022-02-01
Colecção:Epigenetics
Assuntos:
risk snps
bisulphite sequencing
dna methylation
enhancers
lung cancer
dmr
Acesso em linha:http://dx.doi.org/10.1080/15592294.2021.1878723

Internet

http://dx.doi.org/10.1080/15592294.2021.1878723

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