High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer

High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer

The maintenance of DNA sequence integrity is critical to avoid accumulation of cancer-causing mutations. Inactivation of DNA Mismatch Repair (MMR) genes (e.g., MLH1 and MSH2) is common among many cancers, including colorectal cancer (CRC) and is the driver of classic microsatellite instability (MSI)...

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Bibliographic Details
Main Authors: Mudasir Rashid, Rumaisa Rashid, Nikhil Gadewal, John M. Carethers, Minoru Koi, Hassan Brim, Hassan Ashktorab
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
MSH3
Non-synonymous mutation
African American
Colorectal carcinoma
Cancer disparities
Mismatch repair
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624000071

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http://www.sciencedirect.com/science/article/pii/S1476558624000071

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