Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

Abstract Background Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein deposits, typically containing either aberrantly phosphorylated TDP-43 or...

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Bibliographic Details
Main Authors: Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene, Brian C. Kraemer
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Neurodegeneration
Subjects:
Frontotemporal lobar degeneration
TTBK1
TTBK2
TDP-43
Tau
C. elegans
Online Access:http://link.springer.com/article/10.1186/s13024-018-0237-9

Internet

http://link.springer.com/article/10.1186/s13024-018-0237-9

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