Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. While deprivation of d...

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Bibliographic Details
Main Authors: Atsushi Hayashi, Yohei Mikami, Kentaro Miyamoto, Nobuhiko Kamada, Toshiro Sato, Shinta Mizuno, Makoto Naganuma, Toshiaki Teratani, Ryo Aoki, Shinji Fukuda, Wataru Suda, Masahira Hattori, Masayuki Amagai, Manabu Ohyama, Takanori Kanai
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
Lactobacillus murinus
alopecia
gut microbiota
biotin-deficiency
dysbiosis
microbiome
metabolome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310367

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http://www.sciencedirect.com/science/article/pii/S2211124717310367

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