Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice
Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. While deprivation of d...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717310367 |
| _version_ | 1828808886786719744 |
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| author | Atsushi Hayashi Yohei Mikami Kentaro Miyamoto Nobuhiko Kamada Toshiro Sato Shinta Mizuno Makoto Naganuma Toshiaki Teratani Ryo Aoki Shinji Fukuda Wataru Suda Masahira Hattori Masayuki Amagai Manabu Ohyama Takanori Kanai |
| author_facet | Atsushi Hayashi Yohei Mikami Kentaro Miyamoto Nobuhiko Kamada Toshiro Sato Shinta Mizuno Makoto Naganuma Toshiaki Teratani Ryo Aoki Shinji Fukuda Wataru Suda Masahira Hattori Masayuki Amagai Manabu Ohyama Takanori Kanai |
| author_sort | Atsushi Hayashi |
| collection | DOAJ |
| description | Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. While deprivation of dietary biotin per se did not affect skin physiology, its simultaneous treatment with vancomycin resulted in hair loss in specific pathogen-free (SPF) mice. Vancomycin treatment induced the accumulation of L. murinus in the gut, which consumes residual biotin and depletes available biotin in the gut. Consistently, L. murinus induced alopecia when monocolonized in germ-free mice fed a biotin-deficient diet. Supplementation of biotin can reverse established alopecia symptoms in the SPF condition, indicating that L. murinus plays a central role in the induction of hair loss via a biotin-dependent manner. Collectively, our results indicate that luminal metabolic alterations associated with gut dysbiosis and dietary modifications can compromise skin physiology. |
| first_indexed | 2024-12-12T08:48:14Z |
| format | Article |
| id | doaj.art-cb905b91773f4a68ad47ab36298d84f0 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-12T08:48:14Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-cb905b91773f4a68ad47ab36298d84f02022-12-22T00:30:23ZengElsevierCell Reports2211-12472017-08-012071513152410.1016/j.celrep.2017.07.057Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in MiceAtsushi Hayashi0Yohei Mikami1Kentaro Miyamoto2Nobuhiko Kamada3Toshiro Sato4Shinta Mizuno5Makoto Naganuma6Toshiaki Teratani7Ryo Aoki8Shinji Fukuda9Wataru Suda10Masahira Hattori11Masayuki Amagai12Manabu Ohyama13Takanori Kanai14Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USADivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanInstitute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, JapanDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, JapanGraduate School of Frontier Sciences, University of Tokyo, Chiba 227-8561, JapanDepartment of Dermatology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Dermatology, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanMetabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. While deprivation of dietary biotin per se did not affect skin physiology, its simultaneous treatment with vancomycin resulted in hair loss in specific pathogen-free (SPF) mice. Vancomycin treatment induced the accumulation of L. murinus in the gut, which consumes residual biotin and depletes available biotin in the gut. Consistently, L. murinus induced alopecia when monocolonized in germ-free mice fed a biotin-deficient diet. Supplementation of biotin can reverse established alopecia symptoms in the SPF condition, indicating that L. murinus plays a central role in the induction of hair loss via a biotin-dependent manner. Collectively, our results indicate that luminal metabolic alterations associated with gut dysbiosis and dietary modifications can compromise skin physiology.http://www.sciencedirect.com/science/article/pii/S2211124717310367Lactobacillus murinusalopeciagut microbiotabiotin-deficiencydysbiosismicrobiomemetabolome |
| spellingShingle | Atsushi Hayashi Yohei Mikami Kentaro Miyamoto Nobuhiko Kamada Toshiro Sato Shinta Mizuno Makoto Naganuma Toshiaki Teratani Ryo Aoki Shinji Fukuda Wataru Suda Masahira Hattori Masayuki Amagai Manabu Ohyama Takanori Kanai Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice Cell Reports Lactobacillus murinus alopecia gut microbiota biotin-deficiency dysbiosis microbiome metabolome |
| title | Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice |
| title_full | Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice |
| title_fullStr | Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice |
| title_full_unstemmed | Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice |
| title_short | Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice |
| title_sort | intestinal dysbiosis and biotin deprivation induce alopecia through overgrowth of lactobacillus murinus in mice |
| topic | Lactobacillus murinus alopecia gut microbiota biotin-deficiency dysbiosis microbiome metabolome |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717310367 |
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