Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome

Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome

Radiation-induced cardiovascular disease is associated with metabolic remodeling in the heart, mainly due to the inactivation of the transcription factor peroxisome proliferator-activated receptor alpha (PPARα), thereby inhibiting lipid metabolic enzymes. The objective of the present study was to in...

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Bibliographic Details
Main Authors: Omid Azimzadeh, Vikram Subramanian, Wolfgang Sievert, Juliane Merl-Pham, Kateryna Oleksenko, Michael Rosemann, Gabriele Multhoff, Michael J. Atkinson, Soile Tapio
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
ionizing radiation
proteomics
label-free quantification
PPARα
fenofibrate
agonist
Online Access:https://www.mdpi.com/2227-9059/9/12/1845

Internet

https://www.mdpi.com/2227-9059/9/12/1845

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