Single-Cell RNA Sequencing With Combined Use of Bulk RNA Sequencing to Reveal Cell Heterogeneity and Molecular Changes at Acute Stage of Ischemic Stroke in Mouse Cortex Penumbra Area

Single-Cell RNA Sequencing With Combined Use of Bulk RNA Sequencing to Reveal Cell Heterogeneity and Molecular Changes at Acute Stage of Ischemic Stroke in Mouse Cortex Penumbra Area

Stroke has been the leading cause of adult morbidity and mortality over the past several years. After an ischemic stroke attack, many dormant or reversibly injured brain cells exist in the penumbra area. However, the pathological processes and unique cell information in the penumbra area of an acute...

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Bibliographic Details
Main Authors: Kang Guo, Jianing Luo, Dayun Feng, Lin Wu, Xin Wang, Li Xia, Kai Tao, Xun Wu, Wenxing Cui, Yixuan He, Bing Wang, Zhenwei Zhao, Zhiguo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
single-cell sequencing
general transcriptome
ischemic stroke
brain cortex penumbra
microglia
cell survival
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.624711/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.624711/full

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