Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor‐Associated Hypertension

Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor‐Associated Hypertension

Background Myosin phosphatase targeting subunit 2 (MYPT2) is an important subunit of cardiac MLC (myosin light chain) phosphatase, which plays a crucial role in regulating the phosphorylation of MLC to phospho‐MLC (p‐MLC). A recent study demonstrated mineralocorticoid receptor‐related hypertension i...

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Bibliographic Details
Main Authors: Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Rie Ito, Keishi Moriwaki, Mizuki Ichikawa, Lupiya Kimena, Yusuf Ali, Masaaki Ito, Celso E. Gomez‐Sanchez, Kaoru Dohi
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aldosterone
cardiac fibrosis
mineralocorticoid receptor
myosin light chain
phosphorylation
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.032828

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.123.032828

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