Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence

Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence

Abstract Background Commensal bacteria like Neisseria meningitidis sometimes cause serious disease. However, genomic comparison of hyperinvasive and apathogenic lineages did not reveal unambiguous hints towards indispensable virulence factors. Here, in a systems biological approach we compared gene...

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Bibliographic Details
Main Authors: Biju Joseph Ampattu, Laura Hagmann, Chunguang Liang, Marcus Dittrich, Andreas Schlüter, Jochen Blom, Elizaveta Krol, Alexander Goesmann, Anke Becker, Thomas Dandekar, Tobias Müller, Christoph Schoen
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Genomics
Subjects:
Neisseria meningitidis
Virulence
Regulatory evolution
Systems biology
Metabolism
Cryptic genetic variation
Online Access:http://link.springer.com/article/10.1186/s12864-017-3616-7

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http://link.springer.com/article/10.1186/s12864-017-3616-7

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