Novel Compound Inhibitors of HIV-1<sub>NL4-3</sub> Vpu

Novel Compound Inhibitors of HIV-1<sub>NL4-3</sub> Vpu

HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate the contribution of Vpu to pathogenesis and lay th...

Full description

Bibliographic Details
Main Authors: Carolyn A. Robinson, Terri D. Lyddon, Hwi Min Gil, David T. Evans, Yury V. Kuzmichev, Jonathan Richard, Andrés Finzi, Sarah Welbourn, Lynn Rasmussen, N. Miranda Nebane, Vandana V. Gupta, Sam Ananthan, Zhaohui Cai, Elizabeth R. Wonderlich, Corinne E. Augelli-Szafran, Robert Bostwick, Roger G. Ptak, Susan M. Schader, Marc C. Johnson
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
HIV
MLV
GaLV
inhibitors
HTS
Online Access:https://www.mdpi.com/1999-4915/14/4/817

Internet

https://www.mdpi.com/1999-4915/14/4/817

Similar Items