Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

The cation-permeable TRPV2 channel is important for cardiac and immune cell function. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few molecules known to activate TRPV2. Using the patch-clamp technique, we discover that CBD can sensitize current responses of...

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Bibliographic Details
Main Authors: Aaron Gochman, Xiao-Feng Tan, Chanhyung Bae, Helen Chen, Kenton J Swartz, Andres Jara-Oseguera
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
TRP channel
TRPV1
TRPV3
gating
channel sensitization
cannabinoids
Online Access:https://elifesciences.org/articles/86166

Internet

https://elifesciences.org/articles/86166

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