Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is an effective treatment for TB. However, extended L...

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Bibliographic Details
Main Authors: Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Mohd Saqib, Samantha J. Nelson, Pauline Maiello, Chelsea M. Causgrove, Cassaundra L. Ameel, Brianne Stein, H. Jacob Borish, Alexander G. White, Edwin C. Klein, Matthew D. Zimmerman, Véronique Dartois, Philana Ling Lin, Christopher M. Sassetti, JoAnne L. Flynn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
MDR-TB
IL-1
linezolid
host-directed therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00891/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00891/full

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