YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

Persistent human papillomavirus (HPV) infection of stratified squamous epithelial cells causes nearly 5% of cancer cases worldwide. HPV-positive oropharyngeal cancers harbor few mutations in the Hippo signaling pathway compared to HPV-negative cancers at the same anatomical site, prompting the hypot...

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Bibliographic Details
Main Authors: Joshua Hatterschide, Paola Castagnino, Hee Won Kim, Steven M Sperry, Kathleen T Montone, Devraj Basu, Elizabeth A White
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
HPV
papillomavirus
YAP1
cell fate
stem cell
PTPN14
Online Access:https://elifesciences.org/articles/75466

Internet

https://elifesciences.org/articles/75466

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