Isolation, Characterization, and Autophagy Function of BECN1-Splicing Isoforms in Cancer Cells

Isolation, Characterization, and Autophagy Function of BECN1-Splicing Isoforms in Cancer Cells

Alternative splicing allows the synthesis of different protein variants starting from a single gene. Human Beclin 1 (<i>BECN1</i>) is a key autophagy regulator that acts as haploinsufficient tumor suppressor since its decreased expression correlates with tumorigenesis and poor prognosis...

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Bibliographic Details
Main Authors: Chinmay Maheshwari, Chiara Vidoni, Rossella Titone, Andrea Castiglioni, Claudia Lora, Carlo Follo, Ciro Isidoro
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
Beclin 1
alternative splicing
autophagy
mitophagy
Bcl-2
isoforms
Online Access:https://www.mdpi.com/2218-273X/12/8/1069

Internet

https://www.mdpi.com/2218-273X/12/8/1069

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