Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

This work developed high drug-load pellets for colon targeting in minimal steps by coupling hot-melt extrusion (HME) with a die-surface cutting pelletizer, offering a potential continuous pellet manufacturing process. Ketoprofen (KTP) was selected as a model drug for this study due to its thermal st...

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Bibliographic Details
Main Authors: Sagar Narala, Dinesh Nyavanandi, Preethi Mandati, Ahmed Adel Ali Youssef, Abdullah Alzahrani, Praveen Kolimi, Feng Zhang, Michael Repka
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Ketoprofen
Pectin
Hot-melt extrusion
Colon targeting
Hydroxypropyl methylcellulose
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156722000470

Internet

http://www.sciencedirect.com/science/article/pii/S2590156722000470

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