Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

RNA G-quadruplexes (RG4) occur in vivo and have regulatory roles in mRNA metabolism. Here the authors show that the guanine residue stretches at the 5’ end of tRNA-derived stress-induced RNAs mediate the formation of tetramolecular RG4 structures, which play a role in the post-transcriptional regula...

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Bibliographic Details
Main Authors: Shawn M. Lyons, Dorota Gudanis, Steven M. Coyne, Zofia Gdaniec, Pavel Ivanov
Format: Article
Language:English
Published: Nature Portfolio 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01278-w