Glucose metabolism is upregulated in the mononuclear cell proteome during sepsis and supports endotoxin-tolerant cell function

Glucose metabolism is upregulated in the mononuclear cell proteome during sepsis and supports endotoxin-tolerant cell function

Metabolic adaptations shape immune cell function. In the acute response, a metabolic switch towards glycolysis is necessary for mounting a proinflammatory response. During the clinical course of sepsis, both suppression and activation of immune responses take place simultaneously. Leukocytes from se...

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Bibliographic Details
Main Authors: Bianca Lima Ferreira, Mônica Bragança Sousa, Giuseppe Gianini Figueirêdo Leite, Milena Karina Colo Brunialti, Erika Sayuri Nishiduka, Alexandre Keiji Tashima, Tom van der Poll, Reinaldo Salomão
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
sepsis
immunometabolism
PBMCs
endotoxin-tolerance
LPS
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051514/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051514/full

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