In Silico and In Vitro Search for Dual Inhibitors of the <i>Trypanosoma brucei</i> and <i>Leishmania major</i> Pteridine Reductase 1 and Dihydrofolate Reductase

In Silico and In Vitro Search for Dual Inhibitors of the <i>Trypanosoma brucei</i> and <i>Leishmania major</i> Pteridine Reductase 1 and Dihydrofolate Reductase

The parasites <i>Trypanosoma brucei</i> (<i>Tb</i>) and <i>Leishmania major</i> (<i>Lm</i>) cause the tropical diseases sleeping sickness, nagana, and cutaneous leishmaniasis. Every year, millions of humans, as well as animals, living in tropical to su...

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Bibliographic Details
Main Authors: Katharina Possart, Fabian C. Herrmann, Joachim Jose, Thomas J. Schmidt
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
<i>Trypanosoma brucei</i>
<i>Leishmania major</i>
human African trypanosomiasis
cutaneous leishmaniasis
pteridine reductase 1 inhibitor
dihydrofolate reductase inhibitor
Online Access:https://www.mdpi.com/1420-3049/28/22/7526

Internet

https://www.mdpi.com/1420-3049/28/22/7526

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