Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes

Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes

Taurine is ubiquitously distributed in mammalian tissues, with the highest levels in the brain, heart, and leukocytes. Taurine reacts with hypochlorous acid (HOCl) to produce taurine chloramine (Tau-Cl) via the myeloperoxidase (MPO) system. In this study, we elucidated the antioxidative and protecti...

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Bibliographic Details
Main Authors: Song-I Seol, In Soon Kang, Ji Seok Lee, Ja-Kyeong Lee, Chaekyun Kim
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Antioxidants
Subjects:
astrocytes
myeloperoxidase (MPO)
nuclear factor E2-related factor (Nrf2)
heme oxygenase 1 (HO-1)
Kelch-like ECH-associated protein 1 (Keap1)
Online Access:https://www.mdpi.com/2076-3921/13/2/169

Internet

https://www.mdpi.com/2076-3921/13/2/169

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