Application of a Deep Eutectic Solvent for the Synthesis of Novel Imidazole-Containing Quinazoline Derivatives as Potent Cytotoxic Agents

Application of a Deep Eutectic Solvent for the Synthesis of Novel Imidazole-Containing Quinazoline Derivatives as Potent Cytotoxic Agents

Background: Drugs containing the 4-anilinoquinazolines scaffold play a critical role in cancer treatment by inhibiting protein kinases, especially tyrosine kinases. In this study, a novel series of 4-anilinoquinazoline derivatives were synthesized and evaluated as cytotoxic agents. Methods: All fina...

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Bibliographic Details
Main Authors: Fatemeh Azmian Moghadam, Sara Dabirian, Amin Ebrahimi Tavani, Parisa Alipour, Mohammad Mojabi, Mehdi Evazalipour, Fatemeh Yousefbeyk, Saeed Ghasemi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-04-01
Series:Pharmaceutical Sciences
Subjects:
4-anilinoquinazoline
cytotoxic activity
deep eutectic solvent
molecular docking
synthesis
wound healing assay
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-30-215.pdf

Internet

https://ps.tbzmed.ac.ir/PDF/ps-30-215.pdf

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