Spike protein is a key target for stronger and more persistent T-cell responses—a study of mild and asymptomatic SARS-CoV-2 infection

Spike protein is a key target for stronger and more persistent T-cell responses—a study of mild and asymptomatic SARS-CoV-2 infection

Objectives: Understanding the immune response in very mild and asymptomatic COVID-19 is crucial for developing effective vaccines and immunotherapies, yet remains poorly characterized. This longitudinal study examined the evolution of interferon (IFN)-γ responses to SARS-CoV-2 peptides in 109 asympt...

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Bibliographic Details
Main Authors: Ivan Ssali, Susan Mugaba, Arthur Kalyebi Watelo, Juliana Bemanzi, Joseph Ssebwana Katende, Gerald Kevin Oluka, Violet Ankunda, Claire Baine, Laban Kato, Nathan Onyachi, Moses Muwanga, Mark Jjuuko, John Kayiwa, Christopher Nsereko, Betty Oliver Auma, Daniela Weiskopf, Alessandro Sette, Tom Lutalo, Monica Musenero, Pontiano Kaleebu, Jennifer Serwanga
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:International Journal of Infectious Diseases
Subjects:
Mild and asymptomatic COVID-19
Spike protein
IFN-γ
Immunodominance
Long-term immunity
Hematological parameters
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971223007142

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http://www.sciencedirect.com/science/article/pii/S1201971223007142

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