Production of Autoreactive Heavy Chain-Only Antibodies in Systemic Lupus Erythematosus

Production of Autoreactive Heavy Chain-Only Antibodies in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is characterized by the overproduction of high-affinity autoreactive antibodies. Here, we show that more than 65.8% of 222 recombinant antibodies derived from 8 SLE patients can be secreted as heavy chain-only antibodies (HCAbs) when expressed in HEK-293T cells. Th...

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Bibliographic Details
Main Authors: Shu Xu, Hong Yang, Yue Zhuo, Yangsheng Yu, Hongyan Liao, Song Li, Yinshi Yue, Kaihong Su, Zhixin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
B cell
plasmablast
heavy chain antibody
polyreactive antibody
autoreactive antibody
somatic hypermutation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00632/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00632/full

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