Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice

Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice

<b>Background</b>: Transient receptor potential ankyrin 1 (TRPA1) activation is implicated in neuropathic pain-like symptoms. However, whether TRPA1 is solely implicated in pain-signaling or contributes to neuroinflammation in multiple sclerosis (MS) is unknown. Here, we evaluated the TR...

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Bibliographic Details
Main Authors: Diéssica Padilha Dalenogare, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Mustafa Titiz, Gaetano De Siena, Francesco De Logu, Pierangelo Geppetti, Romina Nassini, Gabriela Trevisan
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
microglia
astrocyte
oligodendrocyte
pain
neuroinflammation
allodynia
Online Access:https://www.mdpi.com/2073-4409/12/11/1511

Internet

https://www.mdpi.com/2073-4409/12/11/1511

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