Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase

Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase

ABSTRACT N6-methyladenosine (m6A), a ubiquitous RNA modification, is installed by METTL3-METTL14 complex. The structure of the heterodimeric complex between the methyltransferase domains (MTDs) of METTL3 and METTL14 has been previously determined. However, the MTDs alone possess no enzymatic activit...

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Bibliographic Details
Main Authors: Jinbo Huang, Xu Dong, Zhou Gong, Ling-Yun Qin, Shuai Yang, Yue-Ling Zhu, Xiang Wang, Delin Zhang, Tingting Zou, Ping Yin, Chun Tang
Format: Article
Language:English
Published: Oxford University Press 2018-03-01
Series:Protein & Cell
Subjects:
RNA modification
N6-methyladenosine
METTL3
target recognition domain
zinc finger
paramagnetic relaxation enhancement
Online Access:http://link.springer.com/article/10.1007/s13238-018-0518-7

Internet

http://link.springer.com/article/10.1007/s13238-018-0518-7

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