Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Oncogenic RAS (Rat sarcoma) mutations drive more than half of human cancers, and RAS inhibition is the holy grail of oncology. Thirty years of relentless efforts and harsh disappointments have taught us about the intricacies of oncogenic RAS signalling that allow us to now get a pharmacological grip...

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Bibliographic Details
Main Authors: Aoife A. Nolan, Nourhan K. Aboud, Walter Kolch, David Matallanas
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/12/4/553